| 초록 |
A series of block-copolymers containing poly(ethylene glycol) and poly(acrylic acid) were synthesized via nitroxide-mediated radical polymerization with mPEG-modified alkoxyamine initiator. The resulting copolymers were employed to incorporate the cisplatin pharmacophore (PtII), which then leads to the formation of core-shell type nanostructures in aqueous media. By varying the length of the core-forming PAA blocks with a constant mPEG block on the shell, the PtII-containing nanoparticles exhibited completely different colloidal structures, which can be verified by transmission electron microscope and 1H NMR spectroscopy. Compared to the copolymers with short PAA chains, which exhibited the formation of normal micelle structures, the nanoparticles with highly elongated PAA blocks appeared as a ‘crew-cut’ type micelle, showing a relatively poor colloidal stability against the protein adsorption. |
