| 초록 |
Polymer nanoparticles, known as common drug carrier, may provide controlled releasing ability to medical device systems. Immobilization of polymer nanoparticles to metal surface, however, is not easy to be achieved, owing to the weak interaction between polymer and metal. Herein, we describe a novel strategy to make metal-adhesive polymer nanoparticles. Binding of nanoparticles to metal surface could be accomplished by a simple dipping method without any additional chemical reactions. The density of immobilized nanoparticles could be controlled by adjusting the feed amount of nanoparticles. The successful binding of nanoparticles onto metal surface was confirmed by XPS and contact angle analysis, and supported by Fe-SEM images. A growth factor was loaded on nanoparticles-immobilized metal surface, and was sustainably released. Fluorescence microscopy verified the loading of the growth factor onto nanoparticles-immobilized metal surface. |
