| 학회 | 한국고분자학회 |
| 학술대회 | 2005년 가을 (10/13 ~ 10/14, 제주 ICC) |
| 권호 | 30권 2호 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | SYNTHESIS AND SOL-GEL TRANSITION BEHAVIOR OF THE REVERSED TEMPERATURE- SENSITIVE STAR-SHAPED BLOCK COPOLYMER |
| 초록 | Abstract Stimuli-sensitive polymers which show a sharp response to environmental small stimuli such as temperature, pH, light, composition, and electric current have been investigated by many researchers. Aqueous solution of biodegradable polyethylene glycol-poly(DL-lactic acid-co-glycolic acid)-polyethylene glycol(PEG-PLGA-PEG) triblock copolymer has been studied as a drug delivery system because it shows sol-gel-sol transition behavior as the temperature increased and it has biodegradability. In our previous work, we developed biodegradable temperature-sensitive star-shaped 4arm PLGA-PEG block copolymers to investigate the effect of architecture on the gelation and micellization properties. But, these polymers formed gels at high concentration (~25 wt%). So, we synthesized biodegradable star shaped 4arm PEG-PLGA block copolymers with the reversed structure. 4arm PEG-PLGA block copolymer was synthesized by bulk ring opening polymerization of DL-lactide and glycolide with 4arm PEG as a multi-functional initiator and Sn(oct)2 as a catalyst. The resulting copolymers were confirmed by NMR and GPC. In concentrated aqueous solution, they also showed sol-gel transition behavior and formed gel at lower concentration than 4arm PLGA-PEG. References 1. M. Malmsten, B. Lindman, Macromolecules, 25, 5440-5445 (1995) 2. B. Jeong et al., Advanced Drug Delivery Review, 54, 37-51 (2002) 3. S. Y. Park, D. G. Han, S. C. Kim, macromolecules, 34, 8821-8824 (2001) |
| 저자 | 이수정1, 한보령2, 박상엽3, 한동근4, 김성철5 |
| 소속 | 1한국과학기술원 / 기능성고분자신소재연구센터, 2LG Chem., 3삼양사, 4한국과학기술(연), 5한국과학기술원 |
| 키워드 | hydrogel; star shaped block copolymer; drug delivery |
