| 학회 |
한국고분자학회 |
| 학술대회 |
2014년 가을 (10/06 ~ 10/08, 제주 ICC) |
| 권호 |
39권 2호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Doxorubicin Conjugated Poly((ethylene)-block-(n-buthyl acrylate)):Stable Controlled Release Doxorubicin Carrier |
| 초록 |
Premature drug release is a limitation of many polymer micelle drug carriers. Chemical conjugation of drugs to polymers through labile linkages is a promising method for addressing this challenge. In this paper we demonstrate a simple approach for achieving such a carrier system. A hydrophobic cancer drug, doxorubicin, was chemically conjugated to the hydrophobic (i.e., PnBA) portion of a PEG-PnBA block copolymer through hydrazone bonds. A hydrazone link is stable under physiological (neutral) pH conditions, but it degrades at low pH (such as in acidic regions of tumors, or in some intracellular compartments). Micellization and degradation properties of this doxorubicin-grafted block copolymer have been characterized under varying pH conditions. The pH-dependent chemotherapeutic properties of this carrier system have been investigated in vitro using HeLa cells. |
| 저자 |
정현중1, 이재원2, 이호영3, 원유연2, 방준하3
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| 소속 |
1고려대, 2School of Chemical Engineering, 3Purdue Univ. |
| 키워드 |
drug release; Doxorubicin; pH-sensitive
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| E-Mail |
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