| 초록 |
The shell cross-linked (SCL) polymeric micelles have been studied for controlled drug delivery. In this study, the SCL Tetronic-Tyramine (Tet-TA) micelles were developed using enzymatic reaction to improve micelle stability and to control the drug release behavior. The SCL micelles were prepared by direct dissolution method in the presence of horseradish peroxidase and hydrogen peroxide. The size distribution of the SCL micelles was ranged from 20 to 30 nm, approximately. The morphologies of the SCL micelles were observed by AFM and TEM. In addition, the cross-linking degree of the SCL micelles was analyzed by DSC through the Tm and Tg value. In vitro indomethacin release profiles showed that the shell cross-linking allows the micelles to enhanced stability and controlled drug release behavior by different cross-linking degree. Obtained results demonstrated that the SCL Tet-TA micelles have prominent potentials as an effective drug carrier for controlled drug delivery. |
