| 초록 |
Recently, polymeric hydrogels have received remarkable attention in the pharmaceutical industry. The hydrogels consist of crosslinked hydrophilic polymers. Because of it, they are applicable to various biomedical fields. Especially, the networks of hydrogels can control the release of drugs. In this study, a novel system was discovered which uses a drowning-out crystallization method: The gelation of atorvastatin (ATV) occurs in presence of polyacrylic acid (PAA). Atorvastatin is useful to lower the concentration of bad cholesterol. PAA interacts with atorvastatin resulting in limited crystallization. As a result, the particle size of drug is reduced. After crystallization, whole crystallized solution became a hydrogel. This phenomenon made the drug amorphous. In a gel state, elastic modulus (G′) was higher than viscous modulus (G″). Atorvastatin in the hydrogel shows sustained release patterns. This gelation system will offer a novel delivery of ATV. |
