| 초록 |
Coaxial electrospinning technique has a potential for encapsulating bioactive molecules such as growth factors as well as producing highly porous and fibrous scaffolds with tailored surface properties by co-processing two materials through a facile one-step procedure. In this study, coaxial electrospinning technique was introduced to prepare core-shell structured microfibers (CSFs) encapsulating bFGF, composed of outer PLGA and inner hyaluronic acid (HA) layers. The morphology and core-shell structure of the CSFs was observed by SEM, TEM, and CLSM. The thickness of the layers could be controlled by the variation of the flow rate, which affected the release profile of the encapsulated growth factor. In the release study, bFGF was released from the CSFs over 24 hrs and the release rate could be controlled by the thickness of the outer shell. Obtained results demonstrated that the CSFs may be a promising scaffold releasing growth factors in controlled manner for tissue regeneration. |
