| 초록 |
Over the recent years, drug carriers with plasmonic metal nanostructure for phototherapy has received increasing attention due to its a powerful non-invasive technique for various cancer treatments. Especially, the gold nanoparticles (AuNP) have recently gained outstanding interests owing to their size and shape dependent plasmonic optical properties, ease of functionalization, and the ability to penetrate the cell membranes. The potential application of AuNP in cancer treatment involves targeted drug delivery and photodynamic therapy (PDT). In this study, we developed a gold nanorod (AuNR)-based system for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT). A series of GNRs with different aspect ratio were synthesized by seeded growth method. Then, FA-conjugated block copolymers were employed to modify GNRs and photosensitizers were covalently incorporated into the AuNRs conjugates through the glutathione-sensitive linkages. The physicochemical properties of the multifunctional AuNRs-based system were evaluated. |
