| 학회 |
한국공업화학회 |
| 학술대회 |
2016년 봄 (05/02 ~ 05/04, 여수 엑스포 컨벤션) |
| 권호 |
20권 1호 |
| 발표분야 |
생체재료_포스터 |
| 제목 |
Preparation of titanium-interactable chitosan derivative for development of implant enhanced osteoblast adhesion |
| 초록 |
Titanium-interactable chitosan derivative (P-LMC) was prepared by introducing a phosphonate group from 4-phosphonobutyric acid to low-molecular-weight chitosan. Incorporation of the phosphonate group was confirmed by 31P-NMR. Characterization of titanium surface treated with P-LMC was by XPS and water contact angle. P-LMC could interact with implant surface and made surface more hydrophilic. Prepared P-LMC should have no toxicity for medical applications. Cytotoxicity was tested in WST-8 assays using the C2C12 cell line. Improvements in cell adhesion on treated titanium surfaces were observed by microscopy and the number of attached cells was counted. Implant surface with biocompatible P-LMC had positive effect on cell adhesion. In conclusion, it is considered that P-LMC could be applied as implant coating material to enhance osteoblast adhesion. |
| 저자 |
김은혜, 정진홍, 한가득, 김재원, 노승현, 손태일
|
| 소속 |
중앙대 |
| 키워드 |
Chitosan; implant; osteoblast adhesion; biocompatible; coating material
|
| E-Mail |
|
