| 초록 |
Cell adhesion to extracellular matrix (ECM) is critical to decide cell’s fate, such as cell proliferation, migration, and differentiation, in living body or in culture system. Within stem cell research as well as tissue engineering, synthetic biomimetic materials have been designed as artificial ECMs (art-ECMs) to stimulate cell adhesion and particular cellular functions and the resulting field has been termed “matrix engineering”. Significant progress has been made in the use of naturally derived ECM components or modified ECM molecules as cell adhesion matrices. Synthetic biomimetic materials have been designed as art-ECMs to stimulate cell adhesion and specific cellular functions. Specifically, Arg-Gly-Asp (RGD) and many other oligopeptides that bind to adhesion receptors such as integrin have been incorporated into biomaterials to control cell adhesion, cell morphology, and specific functions. In our strategies, bioactive polypeptides, such as growth factor (GF) or cytokine, fused materials have been employed as art-ECMs to enhance selective interactions between materials and stem cells and to induce specific differentiation of the cells. In this lecture, we will discuss some of the recent advances in matrix design for stem cell functions. |
