| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 가을 (10/07 ~ 10/08, 대구 EXCO) |
| 권호 |
35권 2호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Preparation and Characterization of LMWSC-PEG-RGD for Targeted Gene Delivery |
| 초록 |
A targeted polymeric gene delivery system, LMWSC-PEG-RGD, was developed by incorporating the αvβ3 integrin-binding RGD peptide,(A bicyclic RGD peptide, H-Glu[cyclo(Arg-Gly-Asp-D-Phe-Lys)]2, was recently reported to possess high affinity for αvβ3 integrin.), into the cationic polymer, LMWSC via a hydrophilic polyethylene glycol (PEG) spacer. We synthesized LMWSC-PEG-RGD conjugate and the physicochemical properties of the LMWSC-PEG-RGD were investigated by using 1H-NMR, Dynamic light scattering and Transmission Electron Microscope (TEM). The LMWSC-PEG-RGD was investigated to gene carrier. This research was supported by Basic Science Reaseach Program through the National Research Foundation of Korea(NRF) funded b the Ministry of Education, Science and Technology(2010-0006637). |
| 저자 |
박준규, 홍락준, 손창희, 강승현, 남정표, 최창용, 나재운, 장미경
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| 소속 |
순천대 |
| 키워드 |
LMWSC; Chitosan; Target; RGD; gene carrier
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| E-Mail |
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