| 학회 |
한국공업화학회 |
| 학술대회 |
2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center)) |
| 권호 |
24권 1호 |
| 발표분야 |
포스터-생체재료 |
| 제목 |
pH-responsive degradable nanoparticles for improving the angiogenic efficacy of adult stem cell derived conditioned medium |
| 초록 |
This research demonstrated the effect of using AuFe nanoparticles (NPs) and the availability of high passage number adult stem cells in wound healing using the nanoparticles. Treatment of high passage number hMSCs with AuFe NPs significantly enhanced the secretion of angiogenic paracrine factors and the expression of antiapoptotic genes compared to that in high passage number hMSCs without AuFe NPs treatment. Accordingly, the conditioned medium (CM) collected from AuFe NP-treated high passage number hMSCs dramatically enhanced the wound healing in a mouse. Our result implies that AuFe NPs treatment of high passage number stem cells could suggest a new platform for collecting therapeutically efficient CM. |
| 저자 |
임광범1, 김영환1, 김유진1, 김성원1, 유태경2, 방석호1
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| 소속 |
1성균관대, 2경희대 |
| 키워드 |
angiogenesis; high passage; mesenchymal stem cell; nanoparticle
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| E-Mail |
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