| 학회 |
한국고분자학회 |
| 학술대회 |
2021년 가을 (10/20 ~ 10/22, 경주컨벤션센터) |
| 권호 |
46권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Reduction-reactive drug carrier prepared as thiolated TEMPO-modified cellulose nanofibers and alginate |
| 초록 |
Reduction–responsive microspheres which composed of alginate and thiolated TEMPO-modified cellulose nanofiber (Th-TCNF) were prepared using a spray-dried method and an oxidizing agent (e.g. dimethylsulfoxide (DMSO)). TCNF was prepared by thiolation by covalent bonding of cysteamine to cellulose nanofibers. This was demonstrated by 1H NMR and FT-IR spectroscopy. IPN microspheres obtained by crosslinking were likely to have less indentation on the surface. The results of the images taken through energy dispersive spectroscopy confirmed that alginate and Th-TCNF were cross-linked and revealed that the disulfide bonds tended towards the surface of the microspheres. The disulfide bond of IPN microspheres is reduced and the bond is broken, resulting in reduction-responsive drug release. The higher the Th-TCNF content, the more sensitive it was to reduction. |
| 저자 |
박수찬, 자오, 김진철
|
| 소속 |
강원대 |
| 키워드 |
Interpenetrating network; spray-dried; crosslinking; Microsphere; Reduction
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| E-Mail |
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