| 학회 |
한국화학공학회 |
| 학술대회 |
2010년 봄 (04/22 ~ 04/23, 대구 EXCO) |
| 권호 |
16권 1호, p.407 |
| 발표분야 |
생물화공 |
| 제목 |
Efficientively release controllable electrospun nanofiber using hydrogel microstructure |
| 초록 |
One of important factors in drug therapy is control of drug release. In this study, our aim is release control using electrospun fibers and hydrogels. Polycarprolactone (PCL) which is a biodegradable polymer was used as fiber and the Polyethylene glycol (PEG) based hydrogel surround the fibers. Coaxial electrospinning was proposed as a one-step process for producing core-sheath nanofibers, which showed to prolong the time period of delivery effectively. However, single-nozzle electrospinning is more favorable than coaxial spinning, because a simple process and easy scale-up are essential requirements for reproducible production on a massive scale. The complex of electrospun fibers and hydrogel makes possible to control the release easily from single-nozzle electrospinning. Moreover we can fabricate microstructures such as microparticles using this method. So we expect this system will provide a new useful release system. |
| 저자 |
박영하, 이 열, 박상필, 장은지, 남승희, 이현종, 손경진, 이영민, 고원건
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| 소속 |
연세대 |
| 키워드 |
electrospinning; release control; hydrogel
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| E-Mail |
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| 원문파일 |
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