| 학회 | 한국공업화학회 |
| 학술대회 | 2022년 봄 (05/11 ~ 05/13, 제주국제컨벤션센터(ICC JEJU)) |
| 권호 | 26권 1호 |
| 발표분야 | 미원상사 신진과학자포럼 |
| 제목 | Dirhodium immobilized hollow fiber flow reactor for C–H functionalization in continuous flow |
| 초록 | C−H functionalization hasbecome an exciting new synthetic strategy that has brought significantinnovation into fine chemistry and drug development. In recent years,rhodium-stabilized donor/acceptor carbenes have proven to be effective in awide range of intermolecular C−H functionalization reactions, in which the siteselectivity and stereoselectivity are dominated by catalyst control. This presentation introduces tandem flow reactorswhere the reactive donor/acceptor-substituted diazo compounds are synthesizedin flow from hydrazones, and immediately convert the diazo compounds in asecond, downstream polymeric hollow fiber flow reactor containing supportedasymmetric dirhodium catalysts. Enantioselective cyclopropanation and C-Hfunctionalizations are described, giving similar performance as conventionalbatch reactions. |
| 저자 | 유천재 |
| 소속 | 한국과학기술(연) |
| 키워드 | C-H functionalization; hollow fiber; dirhodium; diazo |
