| 학회 | 한국공업화학회 |
| 학술대회 | 2021년 가을 (11/03 ~ 11/05, 대구 엑스코(EXCO)) |
| 권호 | 25권 2호 |
| 발표분야 | 포스터-콜로이드·계면화학 |
| 제목 | Pectin microgel formation via photopolymerization for macrophage-targeted delivery |
| 초록 | Macrophage is an important target cell in immunotherapy, because it plays a crucial role in not only systemic immune response, but cancer development. In particular, macrophage polarization in tumor microenvironment is a key factor to govern tumor suppression as well as progression. To form a carrier for macrophage targeting, we fabricated microgels using pectin extracted from the root bark of Ulmus davidiana var. japonica (UDP). We modified UDP with methacrylic anhydride for photo-crosslinking and microgel was formed in a simple method via mechanical crushing of pectin hydrogel using homogenizer. The microgel was internalized by THP-1 derived macrophages and upregulated M1 polarization markers. These findings suggest that UDP microgel is a candidate in macrophage regulation. ** This study was supported by the National Research Foundation of Korea (NRF) funded by the Ministry of Education (NRF-2018R1D1A1B07040361) and funded by the Ministry of Science and ICT (NRF- 2020R1A4A1018017). |
| 저자 | 최재호, 기창석 |
| 소속 | 서울대 |
| 키워드 | pectin; microgel; immunomodulatory; macrophage |
