| 초록 |
The aim of this study is to induce drug release of cellulose-based molecularly imprinted transdermal film containing melanin (MIP film) by near infrared (NIR) laser. For MIP film, methacrylic acid (MAA) as functional monomer was grafted carboxymethyl cellulose by free radical polymerization. The methotrexate (MTX), template molecule, was recognized by hydrogen bonding to MAA. After the MTX was extracted from MIP film, equal-sized pore was observed than non-imprinted film. To confirm selective recognition of MTX, folic acid (FA) with chemical structure similar to MTX was used. The MIP film recognized selectively MTX more than FA. After melanin, photothermal agent, was added into MIP film, the surface temperature of MIP film rose by 20 degrees after NIR laser irradiation. The release rate of MTX from MIP film increased rapidly after the laser irradiation. These results indicate that the MIP film is expected to be useful as a transdermal film for releasing drugs by photo-heat conversion. |
