| 초록 |
This study was investigated on the bone-regenerative effect of carbonated hydroxyapatite and acetylated chitosan for guided bone regeneration barrier. Chitosan was acetylated in order to inhibit in vivo inflammatory response. Hydroxyapatite was carbonated to neutralize intense basic hydroxyapatite and to mimic the surface of the natural bone. The composite film barriers were prepared by blending of acetylated chitosan with carbonated nano-size hydroxyapatite. The composite barriers were characterized by SEM, XRD, FTIR, z-potential analyzer, ICP, contact angle analyzer. We investigated that the physical properties of the barriers, such as absorption capacity, surface energy, enzyme-degradation ability according to degree of acetylation and carbonation, and that the biological properties evaluated by MTT assay using osteoblast-like cell; MG-63. The result of MTT assay showed excellent cell viability on composite barriers of 50/50 ratio. |
