| 학회 |
한국재료학회 |
| 학술대회 |
2016년 봄 (05/18 ~ 05/20, 여수 디오션리조트 ) |
| 권호 |
22권 1호 |
| 발표분야 |
B. 나노화학/바이오 재료 분과 |
| 제목 |
Physical Characteristics of Doxorubicin Hydrochloride Drug-Doped Salmon DNA Thin Films |
| 초록 |
Double-stranded salmon DNA (SDNA) was doped with doxorubicin hydrochloride drug molecules (DOX) to determine the binding between DOX and SDNA, and DOX optimum doping concentration in SDNA. SDNA thin films were prepared with various concentrations of DOX by drop-casting on oxygen plasma treated glass and quartz substrates. Fourier transform infrared (FTIR) spectroscopy was employed to investigate the binding sites for DOX in SDNA, and electrical and photoluminescence (PL) analyses were used to determine the optimum doping concentration of DOX. The FTIR spectra showed that up to a concentration of 30 μM of DOX, there was a tendency for binding with a periodic orientation via intercalation between nucleosides. The current and PL intensity increased as the DOX concentration increased up to 30 μM, and then as the concentration of DOX further increased, we observed a decrease in current as well as PL quenching. Finally, the optical band gap and second band onset of the transmittance spectra were analyzed to further verify the DOX binding and optimum doping concentration into SDNA thin films as a function of the DOX concentration. |
| 저자 |
하태우1, Bramaramba Gnapareddy2, Sreekantha Reddy Dugasani2, Bjorn Paulson1, Taehyun Hwang2, Taesung Kim2, 오경환1, 박성하2, 김재훈1
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| 소속 |
1연세대, 2성균관대 |
| 키워드 |
Double-stranded salmon DNA (SDNA); doxorubicin hydrochloride drug molecules (DOX); FTIR; spectrophotometry; photoluminescence; optical band gap; second band onset
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| E-Mail |
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