| 초록 |
We introduce a versatile microfluidic approach for fabricating monodisperse polyurethane (PU) elastomer vesicles with amphiphilic poly (glycerin)-poly (ε-caprolactone) (PG-b-PCL) block copolymer. We use W/O/W double emulsions as templates. Each of W/O and O/W interfaces is stabilized via assembly of PG-b-PCL. The oil shell phase consists of PG-b-PCL and volatile solvents. After removal of solvents, the photo-polymerization of PU precursors gave rise to a thin PU elastomer shell. The elastic modulus of shell can be tuned by changing the degree of PU crosslinking. In response to the osmotic pressure, the polymer vesicles showed selective loading and release of probe molecules. The vesicle system fabricated in this study provides a method for drug encapsulation and releasing and has potentials for application to cosmetics, foods, and pharmaceuticals. |
