| 학회 |
한국공업화학회 |
| 학술대회 |
2006년 가을 (11/10 ~ 11/11, 경희대학교(수원캠퍼스)) |
| 권호 |
10권 2호 |
| 발표분야 |
고분자 |
| 제목 |
Supercritical Carbon Dioxide Assisted Solvent-free Preparation of Drug Loaded Poly(DL-Lactide-co-glycolide) Monoliths for Controlled Release Applications |
| 초록 |
Supercritical carbon dioxide(scCO2) was used as a processing medium for the fabrication of drug encapsulated poly(DL-lactide-co-glycolide) PLGA monoliths for their potential application in controlled drug delivery. Highly water-soluble drug molsidomine loaded biocompatible PLGA composites were carried out near ambient conditions in CO2(37°C,180bar) and upon venting CO2 highly porous monoliths were obtained. The in-vitro release of molsidomine from monoliths into aqueous phase was found to be significantly retarded by the encapsulation of drugs by the PLGA. |
| 저자 |
우민희, Yuvaraj Haldoraj, Jae Hyun Bae, 임권택
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| 소속 |
부경대 |
| 키워드 |
Supercritical carbon dioxide; PLGA; Release Applications
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| E-Mail |
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