화학공학소재연구정보센터
학회 한국고분자학회
학술대회 2019년 가을 (10/09 ~ 10/11, 제주컨벤션센터)
권호 44권 2호
발표분야 기능성 고분자
제목 Intramitochondrial Polymerization-induced Self-Assembly (Mito-PISA) using Covalent Bond Controls Cancer Cell Necrosis
초록 The potential use of intracellular polymerization could be new strategy in cancer theranostics. However, the regulation of polymerization has been still challenging due to spatiotemporal control. In this regards, polymerization consisted of reversible bond would be beneficial due to easily decomposable property, reducing side effect. Disulfide bonds are one of dynamic covalent bonds used in the generation of reversible chemical systems. Under slightly basic condition, thiol group are deprotonated to give thiolate which are oxidized to disulfide. The disulfide bond can be decomposed easily into thiolate group under reduced environment. The high concentration and elevated level of ROS provide effective condition to occur polymerization inside mitochondria of cancer cells. The oxidative agents catalyze production of a larger amount of polymer, which generates more oxidative agent as autocatalytic emergency, leading to dysfunction of mitochondria
저자 김상필, 유자형
소속 울산과학기술원
키워드 Mitochondria; polymerization induced self assembly; cancer therapy; dynamic covalent bond
E-Mail jhryu@unist.ac.kr