| 초록 |
An increase in the surface area of an Active Pharmaceutical Ingredient (API) by reducing particle sizes from micro scales to nanometers has been known as an efficient method in improving the bioavailability of water insoluble drugs. Several polymers such as hydroxypropyl cellulose (HPC), Pluronic acid, polyvinylpyrrolidone (PVP) were employed as a stabilizer or dispersant to prevent the nanoparticated drugs from aggregating again during the process of drug formulation. In this study, copolymers of hydrophilic and hydrophobic amino acids were synthesized by ring opening polymerization of their N-Carboxyanhydride monomers and applied as a novel candidate in stabilizing nanoparticulated water insoluble drugs. Nanoparticulates of water insoluble drugs and synthesized amino acid copolymers were successfully prepared in the scale of 160 ~ 300 nm and expected to show improved bioavailability based on the reduced particle size and biocompatibility due to the nature of peptide bonds of empolyed copolymers. Changes in molecular weights and composition ratios between hydrophilic and hydrophobic segments as well as morphology of the copolymers, block and random, were investigated to find out the optimized conditions of copolymers as a stabilizer. |
