| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 봄 (04/09 ~ 04/10, 고려대학교) |
| 권호 | 29권 1호, p.178 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Temperature sensitive sol-gel transition behavior of aqueous solution of biodegradable 4arm star-shaped PLGA-PEG block copolymer |
| 초록 | Aqueous solution of PEO-PPO-PEO block copolymer has been studied as a drug delivery system since it shows temperatire sensitive sol-gel trasition. However, the disadvantages of this block copolymer system are the non-degradability and toxicity, which are important factors in drug delivery. In this study, biodegradable 4armed star-shaped block copolymers of poly(ethylene glycol) (PEG) and poly(DL-lactide-co-glycolide) (PLGA) were synthesized by using nontoxic ethlene glycol, glycerol and pentaerythritol as initiators. The sol-gel trasition behavior of star-shaped block copolymer was compared with that of triblock copolymer and their blends. The temperature-dependant sol-gel transition of the concentrated solution was investigated by the tube tilting method. The critical micelle concentration and micelle size of resulting products were determined UV-Vis spectroscopy and dynamic light scattering. |
| 저자 | 이수정1, 한보령2, 박상엽3, 한동근4, 김성철1 |
| 소속 | 1한국과학기술원 기능성고분자신소재센터, 2LG 화학, 3삼양사, 4한국과학기술(연) |
| 키워드 | sol-gel transition; temperature-sensitive polymer; star-shaped |
