| 초록 |
The main possibilities for improving dissolution are to increase the surface area of an Active Pharmaceutical Ingredient (API) by decreasing the particle size and by optimizing the wetting characteristics of the compound surface. It is necessary to use a stabilizer or dispersant to prevent the nanoparticulated drugs from aggregating again during the process of drug formulation. However, stabilizers available for the processes are too limited to meet various formulation needs. In this study, copolymers of L-lysine and hydrophobic amino acids were synthesized by ring opening polymerization of their NCAs. Stable nanoparticulates of water insoluble drugs with synthesized copolymers were successfully prepared in the scale of 200 ~ 300 nm. To investigate the effect of hydrophobicity of copolymer, phenylalanine, leucine, and alanine were used for as a hydrophobic component. Changes in molecular weights and composition ratios between hydrophilic and hydrophobic segments as well as hydrophobicity of the copolymers were investigated to find out the optimized conditions of copolymers as a stabilizer. |
