| 학회 | 한국고분자학회 |
| 학술대회 | 2004년 가을 (10/08 ~ 10/09, 경북대학교) |
| 권호 | 29권 2호, p.688 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Sol-gel Transition Behavior of Biodegradable PEG-Polyester Triblock and Star-Block Copolymer Solution |
| 초록 | Temperature-sensitive polymers have been studied extensively as drug delivery systems by many researchers for the past decades. The commercial poly(ethylene oxide-b-propylene oxide-b-ethylene oxide) (PEO-PPO-PEO, Pluronic (BASF) or Poloxamer (ICI)) series has become the center of attention to be used as injectable drug delivery system because it shows sol-gel-sol transition behavior as the temperature increased1. However, it has drawbacks such as non-degradability, toxicity, and dissolution of the gel after administration. So, a considerable investigation of biodegradable block copolymers of PEO and polyester is now under way. We developed biodegradable triblock and star-shaped block copolymers consisting of poly(ethylene) (PEO)-b-(DL-lactide-co-glycolide) were synthesized by using nontoxic ethylene glycol, glycerol and pentaerythritol as initiators. The micellization behavior and micelle size of the block copolymer in the dilute solution state were investigated by UV-Vis and dynamic light scattering. The temperature-dependent sol-gel transition behavior of the concentrated solution was investigated by the tube tilting method. The result obtained in this study confirmed the relationship between the sol-gel transition properties and the polymer architecture. 참고문헌 1. B. Jeong et al., Advanced Drug Delivery Review, 54, 37-51 (2002) 2. S. Y. Park, D. G. Han, S. C. Kim, Macromolecules, 34, 8821-8824 (2001) 3. S. Y. Park, S. C. Kim, et al. Macromolecules 36(11), 4115-4124 (2003) |
| 저자 | 이수정1, 한보령2, 박상엽3, 한동근4, 김성철1 |
| 소속 | 1한국과학기술원 / 기능성고분자신소재연구센터, 2LG Chem., 3삼양사, 4한국과학기술(연) |
| 키워드 | sol-gel transition; PLGA-PEG; star-shaped block copolymer |
