| 초록 |
A hybrid biomaterial has been developed in terms of film using alginate as biopolymer, α-TCP as ceramics and CaCl2 as crosslinker. The strong mechanical strength and high flexibility of the film were attributed to the ionic and H-bonding interactions between alginate with α-tricalcium phosphate particles and calcium chloride, which is confirmed by various chemical analyses. The in vitro bone cell (MC3T3) culture and cytotoxicity tests by extracts of the films showed excellent biocompatibility, while in vitro cell viability studies inside the biomaterials ascertained its cell adhesive and non-cytotoxic characteristics. The film release bovine serum albumin (BSA), and dimethyloxalylglycine (DMOG) in a controlled way at pH 7 and 7.4. Finally, experiment data showed that the developed biomaterial (Alg-α-TCP) could show a possibility of its applications in bone tissue engineering. |
