| 학회 |
한국고분자학회 |
| 학술대회 |
2008년 봄 (04/10 ~ 04/11, 컨벤션 뷰로(대전)) |
| 권호 |
33권 1호 |
| 발표분야 |
의료용 고분자 |
| 제목 |
Preparation and characterization of PLGA/geltain double layer microparticles for dual delivery system |
| 초록 |
We prepared double layer microparticles for dual delivery system consisting of poly(lactide-co-glycolide) (PLGA) and gelatin as a synthetic degradable polymer and natural degradable polymer, respectively. First, PLGA particles loading green fluorophore grafted bovine serum albumin (BSA) were prepared and were subsequently encapsulated with gelatin microparticle loading red fluorophore grafted BSA. The fabricated double layer microparticles were observed by fluorescence microscope, scanning election microscope (SEM) and so on. In the microparticles, the green fluorescence was observed at the PLGA particles whereas the red fluorescence was at gelatin region. Furthermore, dual release pattern of each BSA proteins loaded in the microparticles was investigated in buffer solution by ELISA analysis. This double layer microparticles will provide a useful tool to efficiently deliver and control various types of biomolecules such as drug, cytokine, growth factors. |
| 저자 |
최석조1, 이수홍2, 김경민3, 한양규4
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| 소속 |
1Department of Chemistry, 2Hanyang Univ., 3CHA Stem Cell Institute, 4Pochon CHA Univ. |
| 키워드 |
PLGA; Gelatin; dual delivery system; double layer microparticle
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| E-Mail |
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