| 초록 |
Recently, the use of plasmonic metal nanostructures for phototherapy has attracted considerable attention as a powerful non-invasive technique for treating various cancers. Especially, plasmonic gold nanoparticles demonstrate unique size-dependent optical and photothermal properties due to the collective oscillation of free electrons in their conduction bands. In this study, we developed a gold nanorod (GNR)-based system for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT). A series of GNRs with different aspect ratio were synthesized by seeded growth method. Then, FA-conjugated block copolymers were employed to modify GNRs and photosensitizers were covalently incorporated into the GNRs conjugates. The physicochemical properties of the multifunctional GNRs-based system were evaluated. |
