| 초록 |
Nanotubular structures are highly attractive as multifunctional carrier systems, given that a chosen payload can be encapsulated in their inner voids whilst the outer surface can be chemically modified with organic molecules. Along with proteins, lipids and nucleic acids, carbohydrates are the vital components of cells. Despite their importance in these specific recognition processes, individual protein-carbohydrate interactions often are of low affinity and broad specificity. One way to investigate this interaction is to synthesize molecules bearing multiple copies of carbohydrate residues. Nanomaterials with inherent high surface/volume ratio can give more contact surface area to display multivalency. Glyco-conjugates were synthesized to mimic/monitor biological systems such as glyco-carbon nanotubes as a radio-tracer and glyco-dendrimers for the effective drug delivery system. |
