| 초록 |
Although we reported that HPA3NT3, an analogue peptide derived from HP(2-20)(peptide with residues 2-20 of Helicobacter pylori Ribosomal protein L1),was a potent antimicrobial peptide, its cytotoxic acitivity at high concentration was considered when it was applied in vivo as an antimicrobial drug.Interestingly, HPA3NT3 peptide exerted a potent antimicrobial activity as it forms pore in cytoplasmic membrane, while HPA3NT3-A2 peptide bound to nucleic acids and inhibited protein synthesis through penetration into cytoplasm. This study was supported by IPET(Korea Institute of planning & Evaluation for Technology in Food, Agriculture, Forestry & Fisheries) Research Fund in 2009. |
