| 학회 |
한국고분자학회 |
| 학술대회 |
2016년 봄 (04/06 ~ 04/08, 대전컨벤션센터) |
| 권호 |
41권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 I |
| 제목 |
Liquid crystal emulsion with skin-like lamella structure for enhancing percutaneous absorption and cell proliferation |
| 초록 |
External materials cannot penetrate into the skin because of its lamella structure. This lamella structure decreases the diffusion efficiency of skin. So, we used liquid crystal(LC) emulsion instead of o/w emulsion for better skin diffusion efficiency because of its skin-like multi-lamella structure. We used LC emulsion as a carrier of retinyl palmitate. We determined the multi-lamella structure of LC emulsion by freeze-fracture scanning electron microscope. Franz cell diffusion study using synthetic membrane revealed the percutaneous absorption of LC emulsion. In vivo imaging system(IVIS) showed the fluorescent visualization of diffusion efficiency of o/w emulsion and LC emulsion(o/w emulsion : 3.044*10⁹ / LC emulsion : 3.128*10⁹). And we characterized the cellular metabolism and DNA quantity of NIH3T3 cells by MTT Assay and Picogreen assay, respectively. Therefore, we confirmed the enhanced percutaneous absorption and cell proliferation in the LC emulsion compared to o/w emulsion. |
| 저자 |
이솔, 강면구, 유혁상
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| 소속 |
강원대 |
| 키워드 |
lamella structure; diffusion efficiency; percutaneous absorption; cell proliferation
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| E-Mail |
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