| 초록 |
In bone tissue engineering, it is important to develop scaffolds to regulate osteogenic differentiation of adult mesenchymal stem cells (MSCs). Electrospinning has been widely utilized to prepare artificial nanoscaled fibers with ECM-like fibrillar structure since it is easy to control fiber diameters and three-dimensional architecture. To improve cell-compatibility of synthetic nanofibers, many surface modification techniques have been studied, however, structural deformation of synthetic polymers has been reported. In this study, we prepared synthetic nanofibers of PLLA coated with polydopamine (PD-PLLA) and characterized the fibrous morphology and the surface properties. We then cultured hMSCs on the nanofibers to observe the effect of polydopamine on cell responses such as cell adhesion and proliferation. Moreover, we also evaluated the osteogenic differentiation and mineralization of hMSCs cultured on the nanofibers. |
