| 초록 |
Extracellular matrix is an architectural support for tissue and stem cells and provides essential components for cell adhesion and migration. It also plays a pivotal role in regulating cellular behavior via physical interactions with cell surface proteins and soluble growth factors within the extracellular microenvironment. In this study, ECMs derived from FDM and PDM were investigated for their differentiation potential of human bone marrow stromal cells (hBMSC). The cell morphology was quite different depending on the type of substrates, including culture plastic and gelatin-coated surface. The cells were snugly attached to the FDM and PDM alike and proliferated faster than on the gelatin. The results of gene expression and histology suggested that FDM could be more chondrogenic and PDM more osteogenic. This study indicates that naturally assembled matrix can provide hBMSCs with two-dimensional (2D) microenvironment preferential for cell attachment, growth, and differentiation. |
