| 초록 |
Major barriers to the implementation of soft lithography approach in fabrication of microfluidic device include time consuming, multi-step, complex, and especially high-cost involvement for sophisticated designs as micromixers. 3D printing has been considered as a solution to enable simple and economical manufacturing. In this work, by using 3D-printer, complicated Tesla structure microfluidic devices with different obstructions were fabricated easily. The 3D printed Tesla structure microfluidic device with cone-shaped obstructions resulted in the highest mixing effect (up to 100%). The curcumin loaded polymeric nanoparticles obtained by this device show some potential properties to apply in drug delivery system like high homogeneity (PDI< 0.1) and small size (~100 nm). |
