| 학회 |
한국고분자학회 |
| 학술대회 |
2003년 가을 (10/10 ~ 10/11, 부경대학교) |
| 권호 |
28권 2호, p.90 |
| 발표분야 |
특별 심포지엄 |
| 제목 |
Smart Drug Delivery Application of Hierarchically Ordered Nanoporous Materials |
| 초록 |
Work presented here describes an innovative approach for the bioapplication of the hierarchically ordered nanoporous materials to smart drug delivery system. This is a very simple and flexible approach to control the drug-release on the nanometer scale of ordered porous channels based on tailoring network of thermosensitive polymer, poly(N-isopropylacrylamide (PNIPAm). The drug release showed a sustained positive thermosensitive release profile by suggested nanodiffusion mechanism in which the overall release amount was controlled by changing the pore channel size. The efficiency of drug-loaded and drug-release were calculated by solid state UV-Vis. spectrophotometric method comapared the unmodified and PNIPAm-modified nanoporous materials with different pore sizes. The uniform release profile over a defined period of time may be useful for antipyretic delivery in order to maintain the effectiveness of the drug as long as the biological system is infected. The use of biodegradable / thermosensitive polymers in hierarchically ordered nanoporous structure can be useful for smart drug delivery applications |
| 저자 |
장정호, 김경자
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| 소속 |
요업(세라믹)기술원 나노소재응용본부 |
| 키워드 |
Nanoporous structure; Self-assembly; Block copolymers; Controlled drug delivery
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| E-Mail |
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