| 초록 |
Environmentally sensitive hydrogels have enormous potential in various applications. Some environmental variables, such as low pH and elevated temperatures, are found in the body. For this reason, pH/temperature-sensitive biocompatible and biodegradable hydrogels can be used for site-specific controlled drug delivery. In this study, hydrogels based on poly(N-vinylpyrrolidone) (PVP) were synthesized by free radical copolymerization with poly(ε-caprolactone) or poly(ethylene glycol) macromers. These macromers, synthesized by acylation with acryloyl chloride, were used as a crosslinking agent and azobisisobutyronitrile (AIBN) was used for initiator. The degree of crosslinking and degree of hydrophilicity were controlled by varying the relative concentration of crosslinking agent and comonomer. The PVP hydrogels obtained were characterized by FT-IR, DSC, NMR, and SEM. The equilibrium swelling studies were carried out in simulated gastric fluid (SGF) of pH 1.3 and simulated intestinal fluid (SIF) of pH 7.0, respectively. The gels were swollen extensively in SIF when compared to SGF. The results indicate that PVP hydrogels prepared in this study could be useful for localized delivery of drugs. |
