| 초록 |
Nanoparticles are employed for delivering therapeutics into cells. However, size shape, surface chemistry and the presentation of targeting ligands on the surface of nanoparticles can affect circulation half-life and biodistribution, cell specific internalization, excretion, toxicity ,and efficacy. A variety of materials hav been explored for delivering small interfering RNAs (siRNAs). However, conventional dleivery nanoparticles such as liposomes and polymeric systems are heterogenous in size, composition and surface chemsity, and this can lead to suboptimal performance, lack of tissue specificity and potential toxicity. Here, we show that self-assembled DNA tetrahedral nanoparicles with a well-defiend size can deliver siRNAs into cells and silencetarget genes in tumours. |
