| 학회 |
한국고분자학회 |
| 학술대회 |
2010년 봄 (04/08 ~ 04/09, 대전컨벤션센터) |
| 권호 |
35권 1호 |
| 발표분야 |
의료용 고분자 부문위원회 |
| 제목 |
Controlled Release of Growth Factor from Nanohydrogel for Osteogenic Differentiation of Stem Cell |
| 초록 |
For growth factor-induced differentiation of cells and regeneration of a tissue, a sustained release effect is important. Usually, an initial burst or a fast release of growth factor are not so effective for cell differentiation. We developed a novel method for controlled release system of growth factor using nanohydrogel and applied it to tissue engineering. Alginate nanohydrogels containing bone morphogenetic proteins-2 (BMP-2) were prepared by reverse emulsification-diffusion technique. The effects of BMP-2 released from alginate carriers on the differentiation of human bone marrow stromal cells (hBMSCs) into oesteogenic cells are confirmed by RT-PCR, ALP activity, alizarin-red staining and von kossa staining. The growth factor delivery using nanohydrogel is suggested to be a potential method to facilitate differentiation of stem cells in vivo. |
| 저자 |
임현주, 김한도, 오은정, 김태정, 정호윤, 최진현
|
| 소속 |
경북대 |
| 키워드 |
controlled release; nanohydrogel; BMP; osteogenic; BMSC
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| E-Mail |
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