| 학회 | 한국화학공학회 |
| 학술대회 | 2009년 가을 (10/22 ~ 10/23, 일산 KINTEX) |
| 권호 | 15권 2호, p.1388 |
| 발표분야 | 공정시스템 |
| 제목 | Control Coefficient Identification for Various Biological Models |
| 초록 | A systematic approach is proposed for the metabolic control analysis of various dynamic behaviors in biological systems. The complex kinetic models are reduced by identifying their conservation relationships and by doing time scale analysis. Subsequently, the biological systems are categorized into the following three groups: systems in the steady-states, sustained oscillations, or other non-steady states. The sensitivities are measured to calculate the corresponding control coefficients that are defined considering the characteristics of system dynamics. The proposed approach is illustrated with its application to two biological models. ACKNOWLEDGEMENT : This work was supported by the Korean Systems Biology Research Program (M10309020000-03B5002-00000) of the Ministry of Education, Science and Technology (MEST). Further supports by LG Chem Chair Professorship, Microsoft, World Class University Program of MEST and IBM-SUR program are greatly appreciated. |
| 저자 | 윤좌문1, 김 영2, 이상엽1, 박선원1 |
| 소속 | 1한국과학기술원, 2한국기계(연) |
| 키워드 | Metabolic control analysis; dynamic simulation; biological system. |
| 원문파일 | 초록 보기 |
