화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2021년 가을 (10/27 ~ 10/29, 광주 김대중컨벤션센터)
권호 27권 2호, p.1709
발표분야 생물화공
제목 Negative pressure cavitation extraction of paclitaxel from Taxus chinensis and its kinetic analysis
초록 In this study, the recovery efficiency of paclitaxel from Taxus chinensis was remarkably improved through negative pressure cavitation extraction. Most of the paclitaxel could be recovered from the biomass at a negative pressure of -260 mmHg with a one-time extraction in a short operating time (10-20 min). The pseudo-second-order model was suitable for the kinetic analysis, and the diffusion of paclitaxel in the biomass played a dominant role in the overall extraction rate according to the intraparticle diffusion model. As the negative pressure increased (0, -160, -260 mmHg), the extraction rate constant (4.3325-5.9126 mL/mg·min), the effective diffusion coefficient (1.083x10-12-1.377x10-12 m2/s) and the mass transfer coefficient (1.428x10-7-2.371x10-7 m/s) increased.



Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Government of Korea (MSIT) (Grant Number: 2021R1A2C1003186).



Keywords: Paclitaxel, Extraction, Negative pressure, Cavitation, Mass transfer kinetics
저자 민혜수, 김학균, 김진현
소속 공주대
키워드 생물화학공학
E-Mail jinhyun@kongju.ac.kr
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