| 초록 |
Microcapsules whose membrane is designed to have regular pores provide great potential for a wide range of applications such as immuo-isolation of cells, controlled release of drugs, and site-selective catalytic reaction. However, a technology to produce such semipermeable microcapsules still remains a challenge. Here, we employ a phase separation of polymer blends confined in ultrathin middle layer of water-in-oil-in-water (W/O/W) double-emulsion drops to create semipermeable microcapsules. With a capillary microfluidic device, highly monodisperse W/O/W double-emulsion drops are generated, where the middle oil phase is carefully selected as organic solution of two different polymers. The double-emulsion drops are incubated to evaporate organic solvent from the middle layer, which induces phase separation of the polymers in the shell. Selective removal of one polymer leaves behind regular pores in the shell membrane, thereby providing size-selective permeability. |
