| 학회 |
한국공업화학회 |
| 학술대회 |
2017년 봄 (05/10 ~ 05/12, 광주 김대중컨벤센센터(Kimdaejung Convention Center)) |
| 권호 |
21권 1호 |
| 발표분야 |
콜로이드계면화학 |
| 제목 |
Micelle-To-Vesicle Incorporation of Cholesterol-terminated Poly(acrylic acid) for the Labile Surface-Modification of Lipid Vesicles without Cargo-leakages |
| 초록 |
An amphiphilic cholesterol-terminated poly[acrylic acid] (Chol-PAA) that can be self-aggregated into nanoscale micelles in aqueous media has been prepared via nitroxide-mediated radical polymerization for the facile post-formation modification of lipid vesicles. By varying the amount of Chol-PAA addition, the incorporation of Chol-PAA on the liposome templates was verified with zeta potential while the dynamic light scattering measurements revealed the polymer length of Chol-PAA dictated the hydrodynamic diameter of the resulting polymer-grafted vesicles (PGVs). The membrane incorporation process of Chol-PAA was monitored through the fluorescence resonance energy transfer (FRET) study, which showed the relatively labile incorporation property of Chol-PAA, compared to the cholesterol-free PAA and the native cholesterol. These results indicated that Chol-PAA can be exploited for the facile construction of functional polymer-decorated liposomal delivery systems. |
| 저자 |
신현우, 이상민
|
| 소속 |
가톨릭대 |
| 키워드 |
amphiphilic polymer micelles; lipid vesicles; post-modification
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| E-Mail |
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