| 학회 | 한국고분자학회 |
| 학술대회 | 2002년 가을 (10/11 ~ 10/12, 군산대학교) |
| 권호 | 27권 2호, p.190 |
| 발표분야 | 의료용 고분자 부문위원회 |
| 제목 | Bone Formation of Dexamethasone and Vitamin D3-loaded PLGA Scaffolds for Tissue Engineering |
| 초록 | Dexamethasone (Dex) and vitamin D3 (VD3)-loaded biodegradable PLGA scaffolds are synthetic bone substitutes that promote bone formation by osteoconduction and osteoinduction. Dex-VD3 plays as a regulator of osteogenic differentiation of bone marrow stromal cell (BMSC). Dex-VD3/PLGA scaffolds were fabricated using the solvent casting/salt leaching methods and these scaffolds released Dex-VD3 for over 4 weeks in vitro. Dex-VD3/PLGA scaffolds were confirmed in vivo osteogenic potential for tissue engineered bone. From the results, this sustained, besides, constant localized release system can potentially provide Dex-VD3 and encourage calcium and phosphate, which plays an important role for osteoconduction and osteoinduction. These scaffolds may be used for the applications of bone regeneration. Acknowledgment: This work was supported by MOWH (IMT-2000, 01-PJ11-PG9-01NT00-0011). |
| 저자 | 이상진1, 이동헌*2, 최진산**3, 강조아**4, 강길선**, 이영무, 이해방*** |
| 소속 | 1한양대, 2*전북대, 3**전북대, 4***한국화학(연) |
| 키워드 | bone formation; dexamethasone; vitamin D3; PLGA scaffold |
