화학공학소재연구정보센터
학회 한국화학공학회
학술대회 2003년 가을 (10/24 ~ 10/25, 한양대학교)
권호 9권 2호, p.1567
발표분야 고분자
제목 Preparation of PLA scaffolds via Thermally Induced Phase Separation
초록 Poly(L-lactic acid) (PLLA) scaffolds are currently being tested for hard-tissue cell transplantation, and are fabricated by various techniques. Recently, thermally induced phase separation(TIPS) and freeze-drying have been used to prepare 3D macroporous PLLA scaffold. In the present study, we investigated the effect of the addition of PEG-PLLA diblock and PEG on the morphology of PLLA scaffold. A regular and highly interconnected macroporous poly(L-lactic acid)(PLLA) scaffold was fabricated from a PLLA dioxane water ternary system with added polyethylene glycol(PEG)-PLLA diblock using thermally induced phase separation(TIPS). The porous morphology is determined by the final thermodynamic state and controlled by TIPS parameter. MC3T3-El cell, osteoblast like cell line, is seeded and cultured in the produced PLLA scaffold. The porous morphology and cell culture were characterized by scanning electron microscopy(SEM).
저자 이두성, 김현도, 신규철
소속 성균관대
키워드 PLLA ; TIPS
E-Mail dslee@skku.ac.kr
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