| 초록 |
Nanoparticle technologies are significantly impacting the development of both therapeutic and diagnostic agents. At the intersection between treatment and diagnosis, interest has grown in combining both paradigms into clinically effective formulations. A highly efficient theranostic system for photodynamic therapy (PDT) was developed by designing multifunctional and biodegradable block copolymer-gold nanoparticle (AuNP) conjugates. The FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs become so stable that their optical property do not change under very harsh conditions. Then, hydrophobic photosensitizers were conjugated to the stable vectors through pH-sensitive linkage. The particle size, size distribution, and morphology of FA-PEG-P(Asp-Hyd)-DHLA-modified AuNPs were determined. In vitro tests using HeLa cells indicated that the AuNPs based nanocarrier had excellent cellular localization and killed HeLa cells effectively compare to free Pheo under laser radiation. |
