| 학회 |
한국재료학회 |
| 학술대회 |
2011년 봄 (05/26 ~ 05/27, 제주 휘닉스 아일랜드) |
| 권호 |
17권 1호 |
| 발표분야 |
D. Health and Biological Materials(생체 및 의용재료) |
| 제목 |
Fabrication and In-vitro Biological Evaluation of Gelatin-Pectin-BCP Porous Scaffold for Bone Tissue Engineering Application |
| 초록 |
A biodegradable nanocomposite porous scaffold comprising Gelatin (GE), Pectin (P) and Biphasic Calcium Phosphate (BCP) nanoparticles matrix was developed and studied for bone tissue engineering. The composite scaffolds were fabricated by a method combining the gel casting and polymer sponge techniques. The role of BCP nanoparticles in enhancing the mechanical properties of the scaffold was investigated. Compression tests were performed to measure the compressive strength of the porous scaffolds. Scanning electron microscopy was used to examine the morphology of porous. The results showed that the mechanical property of the scaffold was significantly enhanced by the inclusion of BCP nanoparticles. In vitro studies of GE-P-BCP porous scaffold were conducted. To assay the cytocompatibility and cell behavior on the GE-P-BCP porous scaffold, cell attachment and spreading of osteoblast cell MG-63 seeded on the scaffolds were studied. Our results provide a novel and simple method to obtain an adequate scaffold for osteoblast cells and indicate that GE-P-BCP porous scaffold could be a good candidate for bone tissue engineering scaffolds. |
| 저자 |
Nguyen Thuy Ba Linh1, Shin Woo Kim2, Hun Mo Yang3, Young Ki Min4, Byong-Taek Lee2
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| 소속 |
1Department of Biomedical Eng. & Mater., 2School of Medicine, 3Soonchunhyang Univ., 4Department of Physiology |
| 키워드 |
Gelatin; Pectin; BCP; scaffold; bone tissue engineering
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| E-Mail |
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