화학공학소재연구정보센터
학회 한국공업화학회
학술대회 2020년 가을 (10/28 ~ 10/30, 광주 김대중컨벤션센터(Kimdaejung Convention Center))
권호 24권 1호
발표분야 [생체재료] 미래기술을 위한 바이오 소재 혁신
제목 Plant-inspired Gallol-polymer conjugates for Cardiovascular Therapy and Advanced 3D Printing
초록 Gallol is a ubiquitous functional group found in plant polyphenols. Along with mussel-inspired adhesion chemistry, gallol-polymer conjugates have been emerging as biomaterials due to excellent adhesiveness and rapid oxidative crosslinking to prepare easily medical formulations. Here, we present unique properties of plant polyphenols and gallol-polymer conjugates for cardiac tissue targeting and advanced 3D printing. In the first topic, tannic acid – polyphenols which are widely found in plants – is spontaneously complexed with proteins for cardiac tissue targeting. In the second topic, the gallol-modification of extracellular matrix (ECM) components permits suitable viscoelasticity, good shape fidelity for 3D bioprinting and additional functionality such as ‘on-tissue printing’. Our findings for gallol-polymer conjugates would be applicablee to design biomedical formulations with cardiac tissue adhesion and mechanically tunable properties for advanced 3D printing.
저자 신미경
소속 성균관대
키워드 갈롤; 하이드로젤; 3D 프린팅; 약물전달
E-Mail mikyungshin@g.skku.edu