| 학회 |
한국고분자학회 |
| 학술대회 |
2015년 가을 (10/06 ~ 10/08, 대구컨벤션센터(EXCO)) |
| 권호 |
40권 2호 |
| 발표분야 |
기능성 고분자 |
| 제목 |
Synergistic effect of Antifungal peptide and Amphotericin B in antifungal nanoparticle |
| 초록 |
Fungal infections in almost body including the skin, nails, oral cavity, respiratory tract, and urinary tract, or systemic contamination are reported to occur in over a billion patients each year. Recently, the ongoing emergence of antibiotic-resistant fungal strains and the formation of fungal biofilm demand an amphotericin B delivery systems (DDS) and novel antifungal molecules. Herein, we conjugation of the antifungal peptide can contribute as not only a targeting ligand but also synergistic antifungal molecule in fungal therapy for Candida albicans. We propose that this is fungal DDS in an effective candidate in clinical application as fungal therapy system via pH-responsive drug delivery and redox-sensitive drug release. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded the Ministry of Education, Science and Technology (2013R1A1A4A01010701). |
| 저자 |
박성철1, 장미경1, 박영훈1, 김은지1, 김영민1, 김남홍2
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| 소속 |
1순천대, 2KTR |
| 키워드 |
antifungal; peptide; nanoparticle
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| E-Mail |
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