| 초록 |
A low molecular weight hyaluronic acid-based hydrogel was synthesized using acrylated hyaluronic acid. Matrix metalloproteinases (MMPs) sensitive hyaluronic acid-based hydrogels were prepared by conjugating with MMP degradable cross-linker peptides and/or RGDs peptides to mimic the remodeling characteristics of natural extracellular matrices(ECMs). Mechanical properties of these hydrogels were evaluated with different molecular weights of acrylated hyaluronic acid (10kDa and 50kDa) cross-linked by MMP sensitive peptides by measuring elastic modulus, viscous modulus, swelling ratio, and degradation rate. Human mesenchymal stem cells (hMSCs) cultured in the MMP-sensitive hydrogel with RGD peptides showed dramatic cell adhesion and spreading. This hydrogel could be useful in tissue engineering by improving tissue defect regeneration and tissue remodeling. (Acknowledgement: 1.the Brain Korea 21 Project of the MOE & HRD. 2.R01-2003-000-11592 ) |
